CIN chronic interstitial nephritis

CIN is another kidney abnormality that can be recognized with a PKD echo test. CIN means chronic interstitial nephritis; This is a chronic inflammation of the connective tissue in the kidneys, leading to connective tissue increase. This is also popularly called shriveled kidneys. It leads to complaints because less and less healthy kidney tissue remains. The complaints can be: drinking and peeing a lot, eating badly, vomiting, losing weight, bad fur. Blood tests usually also find elevated kidney levels (urea and creatinine) at a later stage.
 Often the disease becomes clinically evident when the kidneys are put under greater strain. That is why it often becomes clear when a female is pregnant or has recently given birth. However, the disease occurs in cats and males.
 CIN can be obtained (usually with older animals) but also hereditary (usually recognizable at a young age). To date, CIN has mainly been found in the Ragdoll. However, there are data to indicate that similar problems can also occur in other breeds. Familiar relationships are clearly present at the Ragdoll, so heredity is very likely. It is not yet clear what the inheritance is like. The more tested and the more information becomes available, the better we can gain insight into this.
 The following can be found in ultrasound: the kidneys are abnormal in shape with an irregular surface. Often one or both kidneys is too small. The bark of the kidneys (outer tissue layer) often becomes wider, whiter and smudged. The marrow (inner tissue layer) is more difficult to recognize. These are also changes that (certainly at an early stage) can only be determined by a trained researcher.